Clone/ABfeature:

(#2V23)

Antibodygeneration:

Thisantibodywasproducedfromahybridoma(mousemyelomafusedwithspleencellsfromarat)immunizedwithhumanrecombinantproteinofIL-1ra.

Antigen:

humanrecombinantproteinofIL-1ra

StABIlity:

Lyophilizedsamplesarestablefor2yearsfromdateofreceiptwhenstoredat-70°C.Reconstitutedantibodycanbealiquotedandstoredfrozenat< -20 °C for at least for six months without detectable loss of activity.

Reconstitution:

Reconstitutetheantibodywith500µlsterilePBSandthefinalconcentrationis200µg/ml.

Description:

IL-1receptorantagoNIST(IL-1ra)wasoriginallyisolatedfromtheurineofpatientswithmonocyticleukemiaandhasalsobeenpurifiedfromadherentmonocytes.Theproteinshows26%aminoacidhomologytoIL-1betaand19%homologytoIL-1alpha.Itwillcompetewitheitherfactorforreceptorbinding,butdoesnotinteractwitheitherone.HumanIL-1rawillbindtobothtypesofIL-1receptor(IandII)onhumancells.Inmouse,IL-1RIIdoesnotbindIL-1ra.